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Search Results for " Platelet-derived growth factor receptor "

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カタログ番号	製品名	別名	ターゲット
T9030	SU4984		FGFR , IGF-1R , PDGFR
	SU4984 is a cell-permeable, ATP-competitive and reversible inhibitor of the fibroblast growth factor receptor 1 (FGFR1).		FGFR , IGF-1R , PDGFR
T5466	Tyrosine kinase-IN-1		VEGFR , FGFR , FLT , PDGFR
	Tyrosine kinase-IN-1 is a multi-targeted tyrosine kinase inhibitor（KDR, Flt-1, FGFR1 and PDGFRα with IC50s of 4nM, 20nM, 4nM, 2 nM ,respectively）		VEGFR , FGFR , FLT , PDGFR
T6996	SU 5402	SU5402	VEGFR , FGFR , PDGFR
	SU 5402 is a potent multi-targeted receptor tyrosine kinase inhibitor with IC50 of 20 nM, 30 nM, and 510 nM for VEGFR2, FGFR1, and PDGF-Rβ, respectively.		VEGFR , FGFR , PDGFR
T16975	TAK-593		VEGFR , PDGFR
	TAK-593 is an effective VEGFR and PDGFR family inhibitor (IC50s: 3.2, 0.95, 1.1, 4.3, and 13 nM for VEGFR1, VEGFR2, VEGFR3, PDFGRα, and PDFGRβ, respectively).		VEGFR , PDGFR
T6091	CP-673451		VEGFR , PDGFR , c-Kit
	CP-673451 is a specific inhibitor of PDGFRα/β (IC50: 10/1 nM) with antiangiogenic and antitumor activity and the selectivity is higher 450-fold than other angiogenic receptors.		VEGFR , PDGFR , c-Kit
T7945	SU14813		VEGFR , PDGFR , c-Kit
	SU14813 is a multi-receptor tyrosine kinase inhibitor with potent antiangiogenesis and antitumor activity (IC50s of 50, 2, 4, 15 nM for VEGFR2, VEGFR1, PDGFRβ and KIT).		VEGFR , PDGFR , c-Kit
T14137	AG 1295		PDGFR
	AG 1295, a selective inhibitor of platelet-derived growth factor receptor (PDGFR) tyrosine-kinase, effectively halts PDGFR autophosphorylation without impacting the autophosphorylation of the EGF receptor[1][2][3][4].		PDGFR
T1777	Nintedanib	BIBF 1120,Intedanib	VEGFR , FGFR , FLT , PDGFR , Src
	Nintedanib (Intedanib) is a triple vascular kinase inhibitor that inhibits VEGFR1, VEGFR2, and VEGFR3 (IC50=34/13/13 nM), FGFR1, FGFR2, and FGFR3 (IC50=69/37/108 nM), PDGFRα, and PDGFRβ (IC50=59/65 nM). Nintedanib has an...		VEGFR , FGFR , FLT , PDGFR , Src
T2415	PP121		Apoptosis , VEGFR , Bcr-Abl , PDGFR , Src , mTOR , Hck
	PP-121 is a multi-targeted inhibitor of PDGFR (IC50: 2 nM), Hck (IC50: 8 nM), mTOR (IC50: 10 nM), VEGFR2(IC50: 12 nM), Src (IC50: 14 nM) and Abl (IC50: 18 nM) , also inhibits DNA-PK (IC50: 60 nM).		Apoptosis , VEGFR , Bcr-Abl , PDGFR , Src , mTOR , Hck
T0097L	Pazopanib	GW786034	VEGFR , FGFR , PDGFR , c-Kit , Autophagy
	Pazopanib (GW786034), a small molecule inhibitor, inhibits multiple protein tyrosine kinases with potential antineoplastic activity. Pazopanib selectively inhibits VEGFR-1, -2 and -3, c-kit and PDGF-R, which may result i...		VEGFR , FGFR , PDGFR , c-Kit , Autophagy
T8976	PD-089828		EGFR , FGFR , PDGFR , Src
	PD 089828 is a competitive inhibitor of the receptor tyrosine kinases FGFR1, PDGFRβ, and EGFR (IC50s = 0.15, 1.76, and 5.47 µM, respectively) and a noncompetitive inhibitor of the nonreceptor tyrosine kinase c-Src (IC50 ...		EGFR , FGFR , PDGFR , Src
T6166	Telatinib	Bay 57-9352	VEGFR , PDGFR , c-Kit
	Telatinib (Bay 57-9352) is an effective inhibitor of VEGFR2/3, c-Kit, and PDGFRα. The IC50s of Telatinib forVEGFR2/3, c-Kit and PDGFRα are 6 nM/4 nM, 1 nM, and 15 nM, respectively.		VEGFR , PDGFR , c-Kit
T0520	Lenvatinib	E7080	VEGFR , FGFR , c-RET , PDGFR , c-Kit
	Lenvatinib (E7080) is a multi-target receptor tyrosine kinase inhibitor that inhibits VEGFR1-3, FGFR1-4, KIT, PDGFR, and RET, and has oral activity. Lenvatinib has the strongest inhibitory activity on VEGFR2 and VEGFR3 (...		VEGFR , FGFR , c-RET , PDGFR , c-Kit
T23127	PD-161570	PD 161570	EGFR , FGFR , PDGFR , Src
	PD-161570 is a potent and ATP-competitive human FGF-1 receptor inhibitor with an IC50 of 39.9 nM and a Ki of 42 nM. PD-161570 also inhibits the PDGFR, EGFR and c-Src tyrosine kinases with IC50 values of 310 nM, 240 nM, a...		EGFR , FGFR , PDGFR , Src
T3476	JI-101	CGI-1842,JI 101	VEGFR , PDGFR , Ephrin Receptor
	JI-101 (CGI-1842) is an oral multi-kinase inhibitor that targets vascular endothelial growth factor receptor type 2 (VEGFR-2), platelet derived growth factor receptor β (PDGFR-β), and ephrin type-B receptor 4 (EphB4).		VEGFR , PDGFR , Ephrin Receptor
T2358	ENMD-2076		Apoptosis , VEGFR , FGFR , FLT , c-RET , PDGFR , Src , Aurora Kinase
	ENMD-2076, a multi-targeted kinase inhibitor, has specific activity against Aurora A, Flt3, KDR/VEGFR2, Flt4/VEGFR3, FGFR1, FGFR2, Src, PDGFRα.
T3570	SU4312	SU 4312,NSC 86429	VEGFR , PDGFR
	SU-4312, also known as DMBI, is a potent and selective inhibitor of VEGFR and PDGFR tyrosine kinases (IC50 values are 0.8 and 19.4 μM respectively). SU4312 (SU 4312) unexpectedly protects against MPP(+) -induced neurotox...		VEGFR , PDGFR
T1452	Axitinib	AG-013736	VEGFR , PDGFR , c-Kit
	Axitinib (AG-013736) is an orally bioavailable tyrosine kinase inhibitor with IC50s of 0.1, 0.2, 0.1-0.3, 1.7, 1.6 nM for VEGFR1, VEGFR2, VEGFR3, c-kit, and PDGFRβ, respectively.		VEGFR , PDGFR , c-Kit
T5109	Avapritinib	BLU-285	PDGFR , c-Kit
	Avapritinib (BLU-285) is a dual inhibitor of the mutant KIT receptor (KIT D816V, IC50: 0.27 nM) and PDGFRα (PDGFRα D842V, IC50: 0.24 nM).		PDGFR , c-Kit
T13178	Toceranib	PHA 291639E,SU11654	VEGFR , PDGFR , c-Kit
			VEGFR , PDGFR , c-Kit
T2500	Cediranib	AZD2171,NSC-732208	VEGFR , FLT , PDGFR , c-Kit , Autophagy
	Cediranib (AZD2171) (AZD2171) is a highly potent (IC50 < 1 nmol/L) ATP-competitive inhibitor of recombinant KDR tyrosine kinase in vitro, also inhibits Flt1/4 (IC50: 5 nM/≤3 nM), similar activity against PDGFRβ and c-Kit...		VEGFR , FLT , PDGFR , c-Kit , Autophagy
T2372	Ponatinib	AP24534	VEGFR , FGFR , Bcr-Abl , PDGFR , Src , c-Kit , Autophagy
	Ponatinib (AP24534) is an orally available, multitargeted kinase inhibitor (IC50s: 0.37/1.1/1.5/2.2/5.4 nM for Abl, PDGFRα, VEGFR2, FGFR1, and Src, respectively).		VEGFR , FGFR , Bcr-Abl , PDGFR , Src , c-Kit , Autophagy
T1836	AZD2932		VEGFR , FLT , PDGFR , c-Kit
	AZD2932 is a potent and multi-targeted kinase inhibitor VEGFR2, PDGFβ, Flt-3, and c-Kit.		VEGFR , FLT , PDGFR , c-Kit
T1792L	Regorafenib monohydrate		Raf , VEGFR , c-RET , PDGFR , c-Kit , Autophagy
	Regorafenib Monohydrate is a novel oral multikinase inhibitor with IC50 values of 13, 4.2, 46, 22, 7, 1.5, 2.5, 28, 19 nM for VEGFR1, murine VEGFR2, murine VEGFR3, PDGFR-β, KIT, RET, RAF-1, B-RAF and B-RAF(V600E) respect...		Raf , VEGFR , c-RET , PDGFR , c-Kit , Autophagy
T8402	Regorafenib Hydrochloride	BAY73-4506 hydrochloride	Raf , VEGFR , c-RET , PDGFR , Autophagy
	Regorafenib Hydrochloride (BAY73-4506 hydrochloride) is a new oral multikinase inhibitor of angiogenic, stromal and oncogenic receptor tyrosine kinases with potent preclinical antitumor activity		Raf , VEGFR , c-RET , PDGFR , Autophagy
TQ0059	Ilorasertib	ABT-348	VEGFR , FLT , c-RET , PDGFR , Aurora Kinase
	Ilorasertib (ABT-348) (ABT-348) is an ATP-competitive multitargeted kinase inhibitor, which inhibits Aurora A/Aurora B/Aurora C (IC50s: 120 nM/7 nM/1 nM). It also suppresses RET tyrosine kinase, PDGFRβ, and Flt1 (IC50s: ...		VEGFR , FLT , c-RET , PDGFR , Aurora Kinase
T8541	Lenvatinib mesylate	E7080 (mesylate)	VEGFR , FGFR , c-RET , PDGFR , c-Kit
	Lenvatinib mesylate (E7080 (mesylate)) is an oral and multi-targeted inhibitor of VEGFR1-3, FGFR1-4, PDGFR, KIT, and RET, with potent antitumor activities.		VEGFR , FGFR , c-RET , PDGFR , c-Kit
T6184	Orantinib	SU6668,TSU-68,NSC 702827	Apoptosis , VEGFR , FGFR , PDGFR
	Orantinib (NSC 702827) , a excellent effective against PDGFR autophosphorylation with Ki of 8 nM, also highly inhibits Flk-1 and FGFR1 trans-phosphorylation. It shows little effect against IGF-1R, Met, Src, Lck, Zap70, A...		Apoptosis , VEGFR , FGFR , PDGFR
T4320	Flumatinib	HHGV678	Bcr-Abl , PDGFR , c-Kit
	Flumatinib (HHGV678) is an orally bioavailable tyrosine kinase inhibitor flumatinib, with potential antineoplastic activity.		Bcr-Abl , PDGFR , c-Kit
T6711	Tyrphostin AG1296	Tyrphostin AG 1296,AG 1296	Apoptosis , FGFR , FLT , PDGFR , c-Kit
	Tyrphostin AG1296 (Tyrphostin AG 1296) is an inhibitor of PDGFR with IC50 of 0.3-0.5 μM, no activity to EGFR.		Apoptosis , FGFR , FLT , PDGFR , c-Kit
T2609	Masitinib	AB1010	Apoptosis , FAK , c-Fms , FGFR , Bcr-Abl , PDGFR , Src , c-Kit , Hck
	Masitinib (AB1010) is a tyrosine-kinase inhibitor used in the treatment of mast cell tumors in animals, specifically dogs. Since its introduction in November 2008 it has been distributed under the commercial name Masivet...
T8900	Seralutinib	GB002	PDGFR
	Seralutinib (GB002) is an inhibitor of inhaled PDGFRα and PDGFRβ. It is used in the study for pulmonary arterial hypertension.		PDGFR
T0374L	Sunitinib	SU 11248	Apoptosis , Mitophagy , VEGFR , FLT , IRE1 , PDGFR , c-Kit , Autophagy
	Sunitinib (SU 11248) is a multi-targeted receptor tyrosine kinase (RTK) inhibitor that inhibits VEGFR2 and PDGFRβ (IC50=80/2 nM). Sunitinib has antitumor activity and can be used for the treatment of kidney cancer and ga...
T35570	Chiauranib	CS2164	c-Fms , VEGFR , FLT , PDGFR , c-Kit , Aurora Kinase
	Chiauranib is a multi-target inhibitor against tumor angiogenesis and exhibits potent anticancer effects. Chiauranib potently inhibits the angiogenesis-related kinases (VEGFR1, VEGFR2, VEGFR3, PDGFRα and c-Kit), mitosis-...		c-Fms , VEGFR , FLT , PDGFR , c-Kit , Aurora Kinase
T8482	Ripretinib	DCC-2618	Apoptosis , VEGFR , FLT , PDGFR , c-Kit
	Ripretinib (DCC-2618) is an orally bioavailable inhibitor of KIT and PDGFRA.		Apoptosis , VEGFR , FLT , PDGFR , c-Kit
T8491	Vorolanib	CM082,X-82	VEGFR , PDGFR
	Vorolanib (X-82) is an orally active VEGFR/PDGFR dual inhibitor.		VEGFR , PDGFR
TQ0235	AC710		FLT , PDGFR , c-Kit
			FLT , PDGFR , c-Kit
T1792	Regorafenib	BAY 73-4506,Fluoro-Sorafenib	Raf , VEGFR , c-RET , PDGFR , c-Kit , Autophagy
	Regorafenib (BAY 73-4506) is a multi-targeted receptor tyrosine kinase inhibitor that inhibits RET, C-RAF, VEGFR2, c-Kit, VEGFR1, and PDGFRβ and is orally active. Regorafenib has antitumor and anti-angiogenic activity.		Raf , VEGFR , c-RET , PDGFR , c-Kit , Autophagy
T4315	Ki20227		c-Fms , VEGFR , CSF-1R , PDGFR , c-Kit
	Ki-20227 is a specific c-Fms tyrosine kinase(CSF1R) inhibitor (IC50: 2 nM). It also has certain inhibitory against VEGFR2(IC50: 12 nM) and c-Kit/PDGFRβ(IC50: 451/217 nM), respectively.		c-Fms , VEGFR , CSF-1R , PDGFR , c-Kit
T6930	Pazopanib Hydrochloride	GW786034,Pazopanib HCl,GW786034 HCl,Votrient HCl,Armala	c-Fms , VEGFR , FGFR , PDGFR , c-Kit , Autophagy
	Pazopanib Hydrochloride (Votrient HCl) is a novel multi-target inhibitor of VEGFR1, VEGFR2, VEGFR3, PDGFR, FGFR, c-Kit and c-Fms with IC50 of 10 nM, 30 nM, 47 nM, 84 nM, 74 nM, 140 nM and 146 nM in cell-free assays, resp...		c-Fms , VEGFR , FGFR , PDGFR , c-Kit , Autophagy
T10157	Regorafénib N-oxyde (M2)		Raf , VEGFR , c-RET , PDGFR , c-Kit , Drug Metabolite
	Regorafénib N-oxyde M2 is an active metabolite of Regorafenib. Regorafenib is a multi-target inhibitor for VEGFR1/2/3, PDGFRβ, RET, Kit, and Raf-1 (IC50s: 13/4.2/46, 1.5, 22, 7, and 2.5 nM).		Raf , VEGFR , c-RET , PDGFR , c-Kit , Drug Metabolite
T8544	Masitinib mesylate	AB-1010 mesylate	Apoptosis , FAK , FGFR , PDGFR , Src , c-Kit
	Masitinib mesylate (AB-1010 mesylate) is a selective and orally bioavailable c-Kit inhibitor (IC50 of 200 nM,540/800 nM,510 nM for human recombinant c-Kit;PDGFRα/β;LynB,respectively).		Apoptosis , FAK , FGFR , PDGFR , Src , c-Kit
T3463	NVP-ACC789	ACC-789,ZK202650	VEGFR , PDGFR
	ACC-789 (NVP-ACC789 (ZK202650); ZK-202650) is an effective, specific and orally active inhibitor of the VEGF receptor tyrosine kinases.		VEGFR , PDGFR
T5001	Nintedanib esylate	Intedanib,BIBF 1120 (esylate),Nintedanib Ethanesulfonate Salt,BIBF 1120	VEGFR , FGFR , PDGFR
	Nintedanib esylate (BIBF 1120 esylate) is a potent triple angiokinase inhibitor for VEGFR1/2/3, FGFR1/2/3 and PDGFRα/β		VEGFR , FGFR , PDGFR
T6350	CHIR-124	CHIR124,CHIR 124	Apoptosis , GSK-3 , FLT , Chk , PDGFR , Src
	CHIR-124 is an effective Chk1 inhibitor (IC50: 0.3 nM). It has 2, 000-fold selectivity against Chk2, 500- to 5, 000-fold less activity against Cdc2 and CDK2/4.		Apoptosis , GSK-3 , FLT , Chk , PDGFR , Src
T6289	Dovitinib	TKI258,CHIR-258	VEGFR , FGFR , FLT , PDGFR , c-Kit
	Dovitinib (CHIR-258) (TKI258, CHIR258) is a multitargeted RTK inhibitor, mostly for class III (FLT3/c-Kit, IC50: 1/2 nM), also effective to class IV (FGFR1/3) and class V (VEGFR1-4) RTKs (IC50: 8-13 nM), less potent to E...		VEGFR , FGFR , FLT , PDGFR , c-Kit
T4191	Multi-kinase inhibitor 1	Multi-kinase inhibitor I	Others , Bcr-Abl , PDGFR , c-Kit
	Multi-kinase inhibitor 1 (Multi-kinase inhibitor I) is a Multi-kinase inhibitor.		Others , Bcr-Abl , PDGFR , c-Kit
T0080	Trapidil	Rocornal,Trapymine,Avantrin,Trapymin,AR-12008	PDGFR , PDE
	Trapidil (Avantrin) is a coronary vasodilator agent. It was originally developed as a vasodilator and anti-platelet agent and has been used to treat patients with ischemic coronary heart, liver, and kidney disease.		PDGFR , PDE
T0374	Sunitinib Malate	Sutent,SU 11248 (Malate),SU 11248,Sunitinib	Apoptosis , Mitophagy , VEGFR , FLT , IRE1 , PDGFR , c-Kit , Autophagy
	Sunitinib Malate (Sunitinib) is an indolinone-based tyrosine kinase inhibitor. It blocks the tyrosine kinase activities of VEGFR2, PDGFRβ (IC50: 80/2 nM), and c-kit.
T7394	Toceranib Phosphate	SU11654 phosphate,PHA 291639 phosphate	VEGFR , Tyrosinase , PDGFR , c-Kit
	Toceranib Phosphate (SU11654 phosphate), is a selective inhibitor of the tyrosine kinase activity of several members of the split kinase RTK family, including Flk-1/KDR, PDGFR		VEGFR , Tyrosinase , PDGFR , c-Kit

Compounds

SU4984

T9030

Synonym:

Target: FGFR, IGF-1R, PDGFR

Tyrosine kinase-IN-1

T5466

Synonym:

Target: VEGFR, FGFR, FLT, PDGFR

SU 5402

T6996

Synonym: SU5402

Target: VEGFR, FGFR, PDGFR

Target: VEGFR, PDGFR, c-Kit

SU14813

T7945

Synonym:

Target: VEGFR, PDGFR, c-Kit

Synonym: BIBF 1120,Intedanib

Target: VEGFR, FGFR, FLT, PDGFR, Src

PP121

T2415

Synonym:

Target: Apoptosis, VEGFR, Bcr-Abl, PDGFR, Src, mTOR, Hck

Pazopanib

T0097L

Synonym: GW786034

Target: VEGFR, FGFR, PDGFR, c-Kit, Autophagy

PD-089828

T8976

Synonym:

Target: EGFR, FGFR, PDGFR, Src

Telatinib

T6166

Synonym: Bay 57-9352

Target: VEGFR, PDGFR, c-Kit

Lenvatinib

T0520

Synonym: E7080

Target: VEGFR, FGFR, c-RET, PDGFR, c-Kit

PD-161570

T23127

Synonym: PD 161570

Target: EGFR, FGFR, PDGFR, Src

JI-101

T3476

Synonym: CGI-1842,JI 101

Target: VEGFR, PDGFR, Ephrin Receptor

ENMD-2076

T2358

Synonym:

Target: Apoptosis, VEGFR, FGFR, FLT, c-RET, PDGFR, Src, Aurora Kinase

SU4312

T3570

Synonym: SU 4312,NSC 86429

Target: VEGFR, PDGFR, c-Kit

Synonym: PHA 291639E,SU11654

Target: VEGFR, PDGFR, c-Kit

Cediranib

T2500

Synonym: AZD2171,NSC-732208

Target: VEGFR, FLT, PDGFR, c-Kit, Autophagy

Ponatinib

T2372

Synonym: AP24534

Target: VEGFR, FGFR, Bcr-Abl, PDGFR, Src, c-Kit, Autophagy

AZD2932

T1836

Synonym:

Target: VEGFR, FLT, PDGFR, c-Kit

Regorafenib monohydrate

T1792L

Synonym:

Target: Raf, VEGFR, c-RET, PDGFR, c-Kit, Autophagy

Regorafenib Hydrochloride

T8402

Synonym: BAY73-4506 hydrochloride

Target: Raf, VEGFR, c-RET, PDGFR, Autophagy

Ilorasertib

TQ0059

Synonym: ABT-348

Target: VEGFR, FLT, c-RET, PDGFR, Aurora Kinase

Lenvatinib mesylate

T8541

Synonym: E7080 (mesylate)

Target: VEGFR, FGFR, c-RET, PDGFR, c-Kit

Orantinib

T6184

Synonym: SU6668,TSU-68,NSC 702827

Target: Apoptosis, VEGFR, FGFR, PDGFR

Flumatinib

T4320

Synonym: HHGV678

Target: Bcr-Abl, PDGFR, c-Kit

Tyrphostin AG1296

T6711

Synonym: Tyrphostin AG 1296,AG 1296

Target: Apoptosis, FGFR, FLT, PDGFR, c-Kit

Masitinib

T2609

Synonym: AB1010

Target: Apoptosis, FAK, c-Fms, FGFR, Bcr-Abl, PDGFR, Src, c-Kit, Hck

Target: Apoptosis, Mitophagy, VEGFR, FLT, IRE1, PDGFR, c-Kit, Autophagy

Chiauranib

T35570

Synonym: CS2164

Target: c-Fms, VEGFR, FLT, PDGFR, c-Kit, Aurora Kinase

Ripretinib

T8482

Synonym: DCC-2618

Target: Apoptosis, VEGFR, FLT, PDGFR, c-Kit

Target: FLT, PDGFR, c-Kit

Regorafenib

T1792

Synonym: BAY 73-4506,Fluoro-Sorafenib

Target: Raf, VEGFR, c-RET, PDGFR, c-Kit, Autophagy

Ki20227

T4315

Synonym:

Target: c-Fms, VEGFR, CSF-1R, PDGFR, c-Kit

Pazopanib Hydrochloride

T6930

Synonym: GW786034,Pazopanib HCl,GW786034 HCl,Votrient HCl,Armala

Target: c-Fms, VEGFR, FGFR, PDGFR, c-Kit, Autophagy

Regorafénib N-oxyde (M2)

T10157

Synonym:

Target: Raf, VEGFR, c-RET, PDGFR, c-Kit, Drug Metabolite

Masitinib mesylate

T8544

Synonym: AB-1010 mesylate

Target: Apoptosis, FAK, FGFR, PDGFR, Src, c-Kit

NVP-ACC789

T3463

Synonym: ACC-789,ZK202650

Target: VEGFR, PDGFR

Nintedanib esylate

T5001

Synonym: Intedanib,BIBF 1120 (esylate),Nintedanib Ethanesulfonate Salt,BIBF 1120

Target: VEGFR, FGFR, PDGFR

CHIR-124

T6350

Synonym: CHIR124,CHIR 124

Target: Apoptosis, GSK-3, FLT, Chk, PDGFR, Src

Dovitinib

T6289

Synonym: TKI258,CHIR-258

Target: VEGFR, FGFR, FLT, PDGFR, c-Kit

Multi-kinase inhibitor 1

T4191

Synonym: Multi-kinase inhibitor I

Target: Others, Bcr-Abl, PDGFR, c-Kit

Trapidil

T0080

Synonym: Rocornal,Trapymine,Avantrin,Trapymin,AR-12008

Target: PDGFR, PDE

Sunitinib Malate

T0374

Synonym: Sutent,SU 11248 (Malate),SU 11248,Sunitinib

Target: Apoptosis, Mitophagy, VEGFR, FLT, IRE1, PDGFR, c-Kit, Autophagy

Toceranib Phosphate

T7394

Synonym: SU11654 phosphate,PHA 291639 phosphate

Target: VEGFR, Tyrosinase, PDGFR, c-Kit

カタログ番号	製品名	別名	ターゲット
T2734	Sennoside B		PDGFR
	Sennoside B is an anthranoid. Anthranoid derivatives are used all over the world as a treatment for constipation.		PDGFR
TN1969	N-(p-Coumaroyl) serotonin		PDGFR
	N-(p-Coumaroyl) Serotonin is a polyphenol isolated from the seeds of safflower. N-(p-Coumaroyl) serotonin has antioxidant, cardioprotective effects after ischemia and antitumor activity, it may be beneficial in improving...		PDGFR
TN2354	Methylnissolin	3-Hydroxy-9,10-dimethoxyptercarpan	ERK , PDGFR
	Methylnissolin (3-Hydroxy-9,10-dimethoxyptercarpan) is derived from Astragalus and has antibacterial and anti-cancer effects.		ERK , PDGFR
T3S0027	Picropodophyllotoxin	AXL 1717,Picropodophyllin	IGF-1R
	Picropodophyllotoxin (AXL 1717) is a cyclolignan alkaloid found in the mayapple plant family (Podophyllum peltatum), and a small molecule inhibitor of the insulin-like growth factor 1 receptor (IGF1R) with potential anti...		IGF-1R

天然物製品

N-(p-Coumaroyl) serotonin

Synonym: 3-Hydroxy-9,10-dimethoxyptercarpan

Target: ERK, PDGFR

Picropodophyllotoxin

T3S0027

Synonym: AXL 1717,Picropodophyllin

Target: IGF-1R

Recombinant Proteins

Species：

Expression System：

Tag：

カタログ番号	製品名	Species	Expression System
TMPY-01139	PDGFRA Protein, Human, Recombinant (His)	Human	HEK293
	PDGFRA, also known as CD140a, together with the structurally homolog protein PDGFRB (CD140b), are cell surface receptors for members of the platelet-derived growth factor family. They are members of the class III subfami...
TMPY-06921	PDGFRA Protein, Cynomolgus, Recombinant (His)	Cynomolgus	HEK293
	PDGFRA, also known as CD140a, together with the structurally homolog protein PDGFRB (CD140b), are cell surface receptors for members of the platelet-derived growth factor family. They are members of the class III subfami...
TMPY-03140	PDGFRB Protein, Rat, Recombinant (His)	Rat	HEK293
	The cluster of differentiation (CD) system is commonly used as cell markers in Immunophenotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules associating with the immu...
TMPY-00385	PDGFRB Protein, Rhesus, Recombinant (hFc)	Rhesus	HEK293
	The cluster of differentiation (CD) system is commonly used as cell markers in Immunophenotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules associating with the immu...
TMPY-03590	PDGFRB Protein, Rhesus, Recombinant (His)	Rhesus	HEK293
	The cluster of differentiation (CD) system is commonly used as cell markers in Immunophenotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules associating with the immu...
TMPY-03474	PDGFRB Protein, Rat, Recombinant (hFc)	Rat	HEK293
	The cluster of differentiation (CD) system is commonly used as cell markers in Immunophenotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules associating with the immu...
TMPY-03825	PDGFRA Protein, Rat, Recombinant (His)	Rat	HEK293
	PDGFRA, also known as CD140a, together with the structurally homolog protein PDGFRB (CD140b), are cell surface receptors for members of the platelet-derived growth factor family. They are members of the class III subfami...
TMPY-03919	PDGFRA Protein, Rat, Recombinant (hFc)	Rat	HEK293
	PDGFRA, also known as CD140a, together with the structurally homolog protein PDGFRB (CD140b), are cell surface receptors for members of the platelet-derived growth factor family. They are members of the class III subfami...
TMPY-05789	PDGFRA Protein, Mouse, Recombinant (hFc)	Mouse	HEK293
	PDGFRA, also known as CD140a, together with the structurally homolog protein PDGFRB (CD140b), are cell surface receptors for members of the platelet-derived growth factor family. They are members of the class III subfami...
TMPY-05608	PDGFRA Protein, Human, Recombinant (His & Avi), Biotinylated	Human	HEK293
	PDGFRA, also known as CD140a, together with the structurally homolog protein PDGFRB (CD140b), are cell surface receptors for members of the platelet-derived growth factor family. They are members of the class III subfami...
TMPY-05787	PDGFRA Protein, Mouse, Recombinant (His)	Mouse	HEK293
	PDGFRA, also known as CD140a, together with the structurally homolog protein PDGFRB (CD140b), are cell surface receptors for members of the platelet-derived growth factor family. They are members of the class III subfami...
TMPY-00900	PDGFRA Protein, Human, Recombinant (hFc)	Human	HEK293
	PDGFRA, also known as CD140a, together with the structurally homolog protein PDGFRB (CD140b), are cell surface receptors for members of the platelet-derived growth factor family. They are members of the class III subfami...
TMPY-05358	PDGFRB Protein, Human, Recombinant	Human	HEK293
	The cluster of differentiation (CD) system is commonly used as cell markers in Immunophenotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules associating with the immu...
TMPY-04937	PDGFRB Protein, Human, Recombinant (His), Biotinylated	Human	HEK293
	The cluster of differentiation (CD) system is commonly used as cell markers in Immunophenotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules associating with the immu...
TMPY-01207	PDGFRB Protein, Human, Recombinant (His)	Human	HEK293
	The cluster of differentiation (CD) system is commonly used as cell markers in Immunophenotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules associating with the immu...
TMPY-05497	PDGFRB Protein, Human, Recombinant (hFc)	Human	HEK293
	The cluster of differentiation (CD) system is commonly used as cell markers in Immunophenotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules associating with the immu...
TMPJ-00735	PDGF-BB Protein, Human, Recombinant	Human	E. coli
	Platelet-Derived Growth Factor Subunit B (PDGFB) belongs to the PDGF/VEGF growth factor family. Platelet-derived growth factor is a potent mitogen for cells of mesenchymal origin. PDGFB can exist either as a homodimer (P...
TMPY-04976	PDGFC Protein, Mouse, Recombinant (His)	Mouse	Yeast
	PDGF-C is a member of the PDGF/VEGF family of growth factors with a unique domain organization and expression pattern. Platelet-derived growth factor receptors (PDGFRs) are catalytic receptors that have intracellular tyr...
TMPY-00664	ANGPT2/Angiopoietin-2 Protein, Human, Recombinant (hFc)	Human	HEK293
	Angiopoietin-2 (ANG 2, or ANGPT2), is a member of the ANG family, which plays an important role in angiogenesis during the development and growth of human cancers. Both ANGPT-1 and ANGPT-2 appear to bind to the tyrosine ...
TMPY-02474	ANGPT2/Angiopoietin-2 Protein, Mouse, Recombinant (His)	Mouse	HEK293
	Angiopoietin-2 (ANG 2, or ANGPT2), is a member of the ANG family, which plays an important role in angiogenesis during the development and growth of human cancers. Both ANGPT-1 and ANGPT-2 appear to bind to the tyrosine ...
TMPY-04168	ANGPT2/Angiopoietin-2 Protein, Cynomolgus, Rhesus, Recombinant (His)	Cynomolgus,Rhesus	HEK293
	Angiopoietin-2 (ANG 2, or ANGPT2), is a member of the ANG family, which plays an important role in angiogenesis during the development and growth of human cancers. Both ANGPT-1 and ANGPT-2 appear to bind to the tyrosine ...
TMPY-05842	IL-11 Protein, Cynomolgus, Recombinant	Cynomolgus	E. coli
	IL11 is a multifunctional cytokine first isolated in 199 from bone marrow-derived stromal cells. It is a key regulator of multiple events in hematopoiesis, most notably the stimulation of megakaryocyte maturation. IL11 i...
TMPY-04178	IL-11 Protein, Mouse, Recombinant	Mouse	E. coli
	IL11 is a multifunctional cytokine first isolated in 199 from bone marrow-derived stromal cells. It is a key regulator of multiple events in hematopoiesis, most notably the stimulation of megakaryocyte maturation. IL11 i...
TMPY-03488	IL-11 Protein, Human, Recombinant	Human	E. coli
	IL11 is a multifunctional cytokine first isolated in 199 from bone marrow-derived stromal cells. It is a key regulator of multiple events in hematopoiesis, most notably the stimulation of megakaryocyte maturation. IL11 i...
TMPK-00481	PDGF R beta/CD140b Protein, Cynomolgus, Recombinant (His)	Cynomolgus	HEK293
	Platelet-derived growth factor receptor (PDGFR) signaling is involved in proliferation and survival in a wide array of cell types.PDGFR-β signalling, via TGF-β signalling, may be crucial for restoration of BBB integrity ...
TMPK-00223	Ephrin B2/EFNB2 Protein, Human, Recombinant (hFc)	Human	HEK293
	Ephrin-B2 controls platelet-derived growth factor receptor β (PDGFRβ) distribution in the VSMC plasma membrane, endocytosis, and signaling in a fashion that is highly distinct from its role in the endothelium. Ephrin-B2 ...
TMPY-02815	PDGFC Protein, Human, Recombinant (His)	Human	Baculovirus-Insect Cells
	PDGF-C is a member of the PDGF/VEGF family of growth factors with a unique domain organization and expression pattern. Platelet-derived growth factor receptors (PDGFRs) are catalytic receptors that have intracellular tyr...
TMPY-02251	PDGFC Protein, Mouse, Recombinant (hFc)	Mouse	HEK293
	PDGF-C is a member of the PDGF/VEGF family of growth factors with a unique domain organization and expression pattern. Platelet-derived growth factor receptors (PDGFRs) are catalytic receptors that have intracellular tyr...
TMPY-00269	PDGFC Protein, Cynomolgus, Recombinant (hFc)	Cynomolgus	HEK293
	PDGF-C is a member of the PDGF/VEGF family of growth factors with a unique domain organization and expression pattern. Platelet-derived growth factor receptors (PDGFRs) are catalytic receptors that have intracellular tyr...
TMPY-00898	PDGFC Protein, Human, Recombinant (hFc)	Human	HEK293
	PDGF-C is a member of the PDGF/VEGF family of growth factors with a unique domain organization and expression pattern. Platelet-derived growth factor receptors (PDGFRs) are catalytic receptors that have intracellular tyr...
TMPY-03440	Sts1 Protein, Human, Recombinant (His)	Human	E. coli
	UBASH3B contains a ubiquitin associated domain at the N-terminus, an SH3 domain, and a C-terminal domain with similarities to the catalytic motif of phosphoglycerate mutase. UBASH3B was found to inhibit endocytosis of ep...
TMPY-01996	SorCS1 Protein, Human, Recombinant (His)	Human	HEK293
	VPS1 domain-containing receptor SorCS1, also known as SORCS1 and SORCS, is a single-pass type I membrane protein that belongs to the SORCS family and SORCS1 subfamily. SORCS1 contains five BNR repeats and one PKD domain....
TMPY-05360	ANGPT2/Angiopoietin-2 Protein, Human, Recombinant (mFc)	Human	HEK293
	Angiopoietin-2 (ANG 2, or ANGPT2), is a member of the ANG family, which plays an important role in angiogenesis during the development and growth of human cancers. Both ANGPT-1 and ANGPT-2 appear to bind to the tyrosine ...
TMPY-06613	ANGPT2/Angiopoietin-2 Protein, Human, Recombinant (His & Avi), Biotinylated	Human	HEK293
	Angiopoietin-2 (ANG 2, or ANGPT2), is a member of the ANG family, which plays an important role in angiogenesis during the development and growth of human cancers. Both ANGPT-1 and ANGPT-2 appear to bind to the tyrosine ...
TMPY-05259	ANGPT2/Angiopoietin-2 Protein, Human, Recombinant (His), Biotinylated	Human	CHO
	Angiopoietin-2 (ANG 2, or ANGPT2), is a member of the ANG family, which plays an important role in angiogenesis during the development and growth of human cancers. Both ANGPT-1 and ANGPT-2 appear to bind to the tyrosine ...
TMPY-04188	ANGPT2/Angiopoietin-2 Protein, Cynomolgus, Rhesus, Recombinant (hFc)	Cynomolgus,Rhesus	HEK293
	Angiopoietin-2 (ANG 2, or ANGPT2), is a member of the ANG family, which plays an important role in angiogenesis during the development and growth of human cancers. Both ANGPT-1 and ANGPT-2 appear to bind to the tyrosine ...
TMPY-00083	ANGPT2/Angiopoietin-2 Protein, Human, Recombinant (His)	Human	HEK293
	Angiopoietin-2 (ANG 2, or ANGPT2), is a member of the ANG family, which plays an important role in angiogenesis during the development and growth of human cancers. Both ANGPT-1 and ANGPT-2 appear to bind to the tyrosine ...
TMPY-00212	ANGPT2/Angiopoietin-2 Protein, Canine, Recombinant (His)	Canine	HEK293
	Angiopoietin-2 (ANG 2, or ANGPT2), is a member of the ANG family, which plays an important role in angiogenesis during the development and growth of human cancers. Both ANGPT-1 and ANGPT-2 appear to bind to the tyrosine ...
TMPJ-00081	CNTF Protein, Human, Recombinant	Human	E. coli
	Ciliary Neurotrophic Factor (CNTF) is a potent survival factor for neurons and oligodendrocytes. CNTF has also been shown to prevent the degeneration of motor axons after axotomy. CNTF is highly conserved across species ...
TMPY-02131	Acid Phosphatase/ACP1 Protein, Human, Recombinant (GST)	Human	E. coli
	The low molecular weight phosphotyrosine phosphatase (LMW-PTP), also known as Acid phosphatase 1 (ACP1), belongs to the low molecular weight phosphotyrosine protein phosphatase family are involved in the regulation of im...